pSET-dCas9

110183 Synthetic Bacterial Expression

Plasmid Information

Purpose
Expression of the dCas9 gene in Streptomyces
Depositor
Yinhua Lu
Article
Zhao et al Biotechnol J. 2018 Jun 3. doi: 10.1002/b
Insert
dCas9
Mutation
D10A, H840A
Promoter
ermE*p
Available Since
July 26, 2018
Availability
Available

Sequence Information

Length
10,158 bp
Topology
circular
Molecule Type
other DNA

Features

CDS 5
Label Gene Product Position Strand
dCas9 catalytically dead mutant of the Cas9 e… 665..4772 Fwd
DNA Sequence
ATGGACAAGAAGTACTCCATCGGCCTGGCGATCGGCACCAACTCCGTCGGCTGGGCCGTCATCACGGACGAGTACAAGGTCCCGTCGAAGAAGTTCAAGGTGCTGGGCAACACGGACCGCCACAGCATCAAGAAGAACCTCATCGGCGCCCTCCTGTTCGACAGCGGCGAGACGGCCGAGGCGACCCGCCTGAAGCGCACGGCGCGGCGGCGGTACACGCGCCGCAAGAACCGCATCTGCTACCTCCAGGAGATCTTCTCCAACGAGATGGCGAAGGTCGACGACTCGTTCTTCCACCGGCTGGAGGAGTCCTTCCTGGTCGAGGAGGACAAGAAGCACGAGCGGCACCCCATCTTCGGCAACATCGTGGACGAGGTGGCCTACCACGAGAAGTACCCGACCATCTACCACCTCCGGAAGAAGCTGGTGGACTCGACCGACAAGGCCGACCTGCGCCTGATCTACCTGGCCCTCGCCCACATGATCAAGTTCCGCGGCCACTTCCTCATCGAGGGCGACCTGAACCCGGACAACTCGGACGTCGACAAGCTGTTCATCCAGCTCGTGCAGACCTACAACCAGCTCTTCGAGGAGAACCCGATCAACGCCTCCGGCGTGGACGCGAAGGCCATCCTGTCGGCCCGCCTCTCGAAGTCCCGGCGGCTCGAGAACCTGATCGCCCAGCTGCCGGGCGAGAAGAAGAACGGCCTCTTCGGCAACCTGATCGCGCTCTCCCTGGGCCTGACGCCGAACTTCAAGTCCAACTTCGACCTCGCCGAGGACGCCAAGCTCCAGCTGTCCAAGGACACGTACGACGACGACCTGGACAACCTCCTGGCGCAGATCGGCGACCAGTACGCGGACCTGTTCCTCGCGGCGAAGAACCTCTCCGACGCGATCCTGCTCAGCGACATCCTCCGCGTCAACACCGAGATCACCAAGGCGCCCCTGTCCGCGAGCATGATCAAGCGCTACGACGAGCACCACCAGGACCTCACCCTGCTGAAGGCCCTGGTCCGCCAGCAGCTCCCGGAGAAGTACAAGGAGATCTTCTTCGACCAGTCCAAGAACGGCTACGCGGGCTACATCGACGGCGGCGCGTCCCAGGAGGAGTTCTACAAGTTCATCAAGCCCATCCTGGAGAAGATGGACGGCACCGAGGAGCTGCTGGTCAAGCTGAACCGGGAGGACCTCCTGCGCAAGCAGCGCACGTTCGACAACGGCTCCATCCCCCACCAGATCCACCTGGGCGAGCTGCACGCCATCCTCCGGCGCCAGGAGGACTTCTACCCGTTCCTCAAGGACAACCGCGAGAAGATCGAGAAGATCCTCACGTTCCGGATCCCGTACTACGTCGGCCCCCTCGCCCGCGGCAACTCCCGCTTCGCGTGGATGACGCGCAAGTCGGAGGAGACGATCACCCCGTGGAACTTCGAGGAGGTGGTGGACAAGGGCGCCTCCGCGCAGTCGTTCATCGAGCGGATGACCAACTTCGACAAGAACCTGCCGAACGAGAAGGTGCTGCCCAAGCACAGCCTCCTGTACGAGTACTTCACGGTCTACAACGAGCTCACCAAGGTGAAGTACGTGACGGAGGGCATGCGGAAGCCGGCGTTCCTGTCCGGCGAGCAGAAGAAGGCCATCGTGGACCTGCTGTTCAAGACGAACCGGAAGGTCACCGTCAAGCAGCTGAAGGAGGACTACTTCAAGAAGATCGAGTGCTTCGACTCGGTCGAGATCAGCGGCGTGGAGGACCGCTTCAACGCGTCGCTGGGCACGTACCACGACCTCCTGAAGATCATCAAGGACAAGGACTTCCTCGACAACGAGGAGAACGAGGACATCCTGGAGGACATCGTGCTGACCCTGACGCTCTTCGAGGACCGGGAGATGATCGAGGAGCGCCTCAAGACCTACGCGCACCTGTTCGACGACAAGGTCATGAAGCAGCTCAAGCGGCGGCGGTACACCGGCTGGGGCCGGCTCTCCCGCAAGCTCATCAACGGCATCCGGGACAAGCAGTCGGGCAAGACCATCCTCGACTTCCTGAAGTCCGACGGCTTCGCCAACCGCAACTTCATGCAGCTGATCCACGACGACAGCCTGACGTTCAAGGAGGACATCCAGAAGGCGCAGGTGTCGGGCCAGGGCGACTCCCTGCACGAGCACATCGCGAACCTGGCCGGCAGCCCGGCCATCAAGAAGGGCATCCTGCAGACGGTCAAGGTGGTCGACGAGCTGGTGAAGGTGATGGGCCGCCACAAGCCCGAGAACATCGTCATCGAGATGGCCCGGGAGAACCAGACCACGCAGAAGGGCCAGAAGAACAGCCGCGAGCGCATGAAGCGGATCGAGGAGGGCATCAAGGAGCTCGGCTCGCAGATCCTCAAGGAGCACCCCGTCGAGAACACCCAGCTCCAGAACGAGAAGCTCTACCTCTACTACCTGCAGAACGGCCGGGACATGTACGTGGACCAGGAGCTCGACATCAACCGGCTGTCGGACTACGACGTGGACGCCATCGTCCCGCAGTCGTTCCTGAAGGACGACAGCATCGACAACAAGGTCCTCACCCGCTCGGACAAGAACCGGGGCAAGTCCGACAACGTCCCGTCGGAGGAGGTCGTGAAGAAGATGAAGAACTACTGGCGGCAGCTCCTCAACGCCAAGCTCATCACGCAGCGCAAGTTCGACAACCTGACGAAGGCGGAGCGGGGCGGCCTCAGCGAGCTCGACAAGGCGGGCTTCATCAAGCGGCAGCTGGTCGAGACGCGGCAGATCACGAAGCACGTGGCCCAGATCCTGGACTCGCGCATGAACACCAAGTACGACGAGAACGACAAGCTGATCCGCGAGGTCAAGGTCATCACCCTCAAGTCCAAGCTGGTGAGCGACTTCCGCAAGGACTTCCAGTTCTACAAGGTGCGGGAGATCAACAACTACCACCACGCCCACGACGCGTACCTGAACGCGGTGGTGGGCACGGCGCTGATCAAGAAGTACCCGAAGCTCGAGAGCGAGTTCGTCTACGGCGACTACAAGGTGTACGACGTGCGGAAGATGATCGCGAAGAGCGAGCAGGAGATCGGCAAGGCCACGGCGAAGTACTTCTTCTACAGCAACATCATGAACTTCTTCAAGACCGAGATCACCCTGGCGAACGGCGAGATCCGCAAGCGCCCGCTCATCGAGACCAACGGCGAGACGGGCGAGATCGTGTGGGACAAGGGCCGCGACTTCGCGACCGTCCGGAAGGTGCTGTCCATGCCCCAGGTCAACATCGTCAAGAAGACGGAGGTCCAGACCGGCGGCTTCAGCAAGGAGTCCATCCTGCCCAAGCGGAACAGCGACAAGCTGATCGCCCGGAAGAAGGACTGGGACCCCAAGAAGTACGGCGGCTTCGACTCCCCCACCGTCGCCTACTCGGTCCTCGTGGTCGCCAAGGTGGAGAAGGGCAAGAGCAAGAAGCTGAAGTCCGTGAAGGAGCTGCTGGGCATCACCATCATGGAGCGGTCGTCGTTCGAGAAGAACCCCATCGACTTCCTGGAGGCCAAGGGCTACAAGGAGGTGAAGAAGGACCTCATCATCAAGCTCCCCAAGTACTCCCTGTTCGAGCTGGAGAACGGCCGGAAGCGCATGCTCGCCAGCGCGGGCGAGCTGCAGAAGGGCAACGAGCTGGCGCTGCCGAGCAAGTACGTCAACTTCCTGTACCTCGCCTCGCACTACGAGAAGCTGAAGGGCTCGCCGGAGGACAACGAGCAGAAGCAGCTGTTCGTGGAGCAGCACAAGCACTACCTCGACGAGATCATCGAGCAGATCTCCGAGTTCTCCAAGCGCGTCATCCTGGCCGACGCGAACCTGGACAAGGTCCTGTCCGCGTACAACAAGCACCGCGACAAGCCGATCCGGGAGCAGGCCGAGAACATCATCCACCTGTTCACGCTGACCAACCTCGGCGCCCCCGCGGCCTTCAAGTACTTCGACACCACGATCGACCGGAAGCGGTACACGAGCACGAAGGAGGTGCTCGACGCCACCCTGATCCACCAGAGCATCACGGGCCTGTACGAGACCCGCATCGACCTCTCCCAGCTGGGCGGCGACTGA
Protein Sequence
MDKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDAIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD
ApmR aac(3)IV aminoglycoside 3-N-acetyltransferase ty… 6144..6945 Fwd
DNA Sequence
ATGTCATCAGCGGTGGAGTGCAATGTCGTGCAATACGAATGGCGAAAAGCCGAGCTCATCGGTCAGCTTCTCAACCTTGGGGTTACCCCCGGCGGTGTGCTGCTGGTCCACAGCTCCTTCCGTAGCGTCCGGCCCCTCGAAGATGGGCCACTTGGACTGATCGAGGCCCTGCGTGCTGCGCTGGGTCCGGGAGGGACGCTCGTCATGCCCTCGTGGTCAGGTCTGGACGACGAGCCGTTCGATCCTGCCACGTCGCCCGTTACACCGGACCTTGGAGTTGTCTCTGACACATTCTGGCGCCTGCCAAATGTAAAGCGCAGCGCCCATCCATTTGCCTTTGCGGCAGCGGGGCCACAGGCAGAGCAGATCATCTCTGATCCATTGCCCCTGCCACCTCACTCGCCTGCAAGCCCGGTCGCCCGTGTCCATGAACTCGATGGGCAGGTACTTCTCCTCGGCGTGGGACACGATGCCAACACGACGCTGCATCTTGCCGAGTTGATGGCAAAGGTTCCCTATGGGGTGCCGAGACACTGCACCATTCTTCAGGATGGCAAGTTGGTACGCGTCGATTATCTCGAGAATGACCACTGCTGTGAGCGCTTTGCCTTGGCGGACAGGTGGCTCAAGGAGAAGAGCCTTCAGAAGGAAGGTCCAGTCGGTCATGCCTTTGCTCGGTTGATCCGCTCCCGCGACATTGTGGCGACAGCCCTGGGTCAACTGGGCCGAGATCCGTTGATCTTCCTGCATCCGCCAGAGGCGGGATGCGAAGAATGCGATGCCGCTCGCCAGTCGATTGGC
Protein Sequence
MSSAVECNVVQYEWRKAELIGQLLNLGVTPGGVLLVHSSFRSVRPLEDGPLGLIEALRAALGPGGTLVMPSWSGLDDEPFDPATSPVTPDLGVVSDTFWRLPNVKRSAHPFAFAAAGPQAEQIISDPLPLPPHSPASPVARVHELDGQVLLLGVGHDANTTLHLAELMAKVPYGVPRHCTILQDGKLVRVDYLENDHCCERFALADRWLKEKSLQKEGPVGHAFARLIRSRDIVATALGQLGRDPLIFLHPPEAGCEECDAARQSIG
traJ traJ oriT-recognizing protein 7378..7750 Rev
DNA Sequence
ATGGCTGATGAAACCAAGCCAACCAGGAAGGGCAGCCCACCTATCAAGGTGTACTGCCTTCCAGACGAACGAAGAGCGATTGAGGAAAAGGCGGCGGCGGCCGGCATGAGCCTGTCGGCCTACCTGCTGGCCGTCGGCCAGGGCTACAAAATCACGGGCGTCGTGGACTATGAGCACGTCCGCGAGCTGGCCCGCATCAATGGCGACCTGGGCCGCCTGGGCGGCCTGCTGAAACTCTGGCTCACCGACGACCCGCGCACGGCGCGGTTCGGTGATGCCACGATCCTCGCCCTGCTGGCGAAGATCGAAGAGAAGCAGGACGAGCTTGGCAAGGTCATGATGGGCGTGGTCCGCCCGAGGGCAGAGCCATGA
Protein Sequence
MADETKPTRKGSPPIKVYCLPDERRAIEEKAAAAGMSLSAYLLAVGQGYKITGVVDYEHVRELARINGDLGRLGGLLKLWLTDDPRTARFGDATILALLAKIEEKQDELGKVMMGVVRPRAEP
Factor Xa site Factor Xa recognition and cleavage site 8129..8141 Rev
DNA Sequence
ATAGAGGGGCGT
Protein Sequence
IEGR
phage phi-C31 integrase integrase from phage phi-C31 8320..10138 Fwd
DNA Sequence
GTGGACACGTACGCGGGTGCTTACGACCGTCAGTCGCGCGAGCGCGAAAATTCGAGCGCAGCAAGCCCAGCGACACAGCGTAGCGCCAACGAAGACAAGGCGGCCGACCTTCAGCGCGAAGTCGAGCGCGACGGGGGCCGGTTCAGGTTCGTCGGGCATTTCAGCGAAGCGCCGGGCACGTCGGCGTTCGGGACGGCGGAGCGCCCGGAGTTCGAACGCATCCTGAACGAATGCCGCGCCGGGCGGCTCAACATGATCATTGTCTATGACGTGTCGCGCTTCTCGCGCCTGAAGGTCATGGACGCGATTCCGATTGTCTCGGAATTGCTCGCCCTGGGCGTGACGATTGTTTCCACTCAGGAAGGCGTCTTCCGGCAGGGAAACGTCATGGACCTGATTCACCTGATTATGCGGCTCGACGCGTCGCACAAAGAATCTTCGCTGAAGTCGGCGAAGATTCTCGACACGAAGAACCTTCAGCGCGAATTGGGCGGGTACGTCGGCGGGAAGGCGCCTTACGGCTTCGAGCTTGTTTCGGAGACGAAGGAGATCACGCGCAACGGCCGAATGGTCAATGTCGTCATCAACAAGCTTGCGCACTCGACCACTCCCCTTACCGGACCCTTCGAGTTCGAGCCCGACGTAATCCGGTGGTGGTGGCGTGAGATCAAGACGCACAAACACCTTCCCTTCAAGCCGGGCAGTCAAGCCGCCATTCACCCGGGCAGCATCACGGGGCTTTGTAAGCGCATGGACGCTGACGCCGTGCCGACCCGGGGCGAGACGATTGGGAAGAAGACCGCTTCAAGCGCCTGGGACCCGGCAACCGTTATGCGAATCCTTCGGGACCCGCGTATTGCGGGCTTCGCCGCTGAGGTGATCTACAAGAAGAAGCCGGACGGCACGCCGACCACGAAGATTGAGGGTTACCGCATTCAGCGCGACCCGATCACGCTCCGGCCGGTCGAGCTTGATTGCGGACCGATCATCGAGCCCGCTGAGTGGTATGAGCTTCAGGCGTGGTTGGACGGCAGGGGGCGCGGCAAGGGGCTTTCCCGGGGGCAAGCCATTCTGTCCGCCATGGACAAGCTGTACTGCGAGTGTGGCGCCGTCATGACTTCGAAGCGCGGGGAAGAATCGATCAAGGACTCTTACCGCTGCCGTCGCCGGAAGGTGGTCGACCCGTCCGCACCTGGGCAGCACGAAGGCACGTGCAACGTCAGCATGGCGGCACTCGACAAGTTCGTTGCGGAACGCATCTTCAACAAGATCAGGCACGCCGAAGGCGACGAAGAGACGTTGGCGCTTCTGTGGGAAGCCGCCCGACGCTTCGGCAAGCTCACTGAGGCGCCTGAGAAGAGCGGCGAACGGGCGAACCTTGTTGCGGAGCGCGCCGACGCCCTGAACGCCCTTGAAGAGCTGTACGAAGACCGCGCGGCAGGCGCGTACGACGGACCCGTTGGCAGGAAGCACTTCCGGAAGCAACAGGCAGCGCTGACGCTCCGGCAGCAAGGGGCGGAAGAGCGGCTTGCCGAACTTGAAGCCGCCGAAGCCCCGAAGCTTCCCCTTGACCAATGGTTCCCCGAAGACGCCGACGCTGACCCGACCGGCCCTAAGTCGTGGTGGGGGCGCGCGTCAGTAGACGACAAGCGCGTGTTCGTCGGGCTCTTCGTAGACAAGATCGTTGTCACGAAGTCGACTACGGGCAGGGGGCAGGGAACGCCCATCGAGAAGCGCGCTTCGATCACGTGGGCGAAGCCGCCGACCGACGACGACGAAGACGACGCCCAGGACGGCACGGAAGACGTAGCGGCGTAG
Protein Sequence
MDTYAGAYDRQSRERENSSAASPATQRSANEDKAADLQREVERDGGRFRFVGHFSEAPGTSAFGTAERPEFERILNECRAGRLNMIIVYDVSRFSRLKVMDAIPIVSELLALGVTIVSTQEGVFRQGNVMDLIHLIMRLDASHKESSLKSAKILDTKNLQRELGGYVGGKAPYGFELVSETKEITRNGRMVNVVINKLAHSTTPLTGPFEFEPDVIRWWWREIKTHKHLPFKPGSQAAIHPGSITGLCKRMDADAVPTRGETIGKKTASSAWDPATVMRILRDPRIAGFAAEVIYKKKPDGTPTTKIEGYRIQRDPITLRPVELDCGPIIEPAEWYELQAWLDGRGRGKGLSRGQAILSAMDKLYCECGAVMTSKRGEESIKDSYRCRRRKVVDPSAPGQHEGTCNVSMAALDKFVAERIFNKIRHAEGDEETLALLWEAARRFGKLTEAPEKSGERANLVAERADALNALEELYEDRAAGAYDGPVGRKHFRKQQAALTLRQQGAEERLAELEAAEAPKLPLDQWFPEDADADPTGPKSWWGRASVDDKRVFVGLFVDKIVVTKSTTGRGQGTPIEKRASITWAKPPTDDDEDDAQDGTEDVAA
promoter 1
Label Gene Product Position Strand
lac promoter 4998..5029 Rev
DNA Sequence
TTTACACTTTATGCTTCCGGCTCGTATGTTG
protein_bind 3
Label Gene Product Position Strand
lac operator 4974..4991 Fwd
DNA Sequence
TTGTTATCCGCTCACAA
CAP binding site 5043..5065 Fwd
DNA Sequence
ATGAGTGAGCTAACTCACATTA
phage phi-C31 attP 8211..8311 Fwd
DNA Sequence
CCCAGGTCAGAAGCGGTTTTCGGGAGTAGTGCCCCAACTGGGGTAACCTTTGAGTTCTCTCAGTTGGGGGCGTAGGGTCGCCGACATGACACAAGGGGTT
rep_origin 1
Label Gene Product Position Strand
ori 5352..5941 Rev
DNA Sequence
TTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTTCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAA